Dr. Oliveira's research interest is in physiological signal processing and systems identification. In particular, she is interested in the modeling and identification of the cardiorespiratory and vascular systems for the quantification of the sympathetic and vagal autonomic nervous system. Her research involves investigation of the interaction between obstructive sleep apnea and the autonomic and metabolic systems.
Physiological systems models can be interpreted as representations of our knowledge about the functional characteristics of the system being studied, obtained from experimental evidence, in the form of mathematical relationships between the physiological variables involved. In this sense, the application of engineering techniques, such as digital signal processing, computational modeling and systems identification, in biological and medical problems, using physiological data, allow for a more detailed understanding of the underlying mechanisms that govern complex physiological systems in the human body, from the celular to the systems level.
Dr. Oliveira's research aims to apply such engineering techniques to model the cardiorespiratory and cardiovascular systems for the determination of quantitative metrics of the autonomic nervous system, based on the analysis of noninvasive physiological records, such as respiration, blood pressure and electrocardiogram (ecg).
CRSIDLab 2.0 - a toolbox for multivariate autonomic nervous system analysis (see publication below). This link contains a tutorial to CRSIDLab and a zipfile containing all Matlab files necessary for running each feature described in the tutorial. The zipped file also contains a more detailed instruction manual, describing every functionality present in the software. Please send any queries and bug reports to: flavia@ene.unb.br.
Journal Papers
Silva, Luisa Santiago C. B. da; Oliveira, Flavia Maria G. S. CRSIDLab: a toolbox for multivariate autonomic nervous system analysis using cardiorespiratory information. IEEE Journal of Biomedical and Health Informatics, 2019 (Early access). DOI: 10.1109/JBHI.2019.2914211
Oliveira, Flavia M. S.; Tran, Winston; Lesser, Daniel J.; Bhatia, Rajeev; Keens, Thomas; Mittelman, Steven D.; Davidson-Ward, Sally; Khoo, Michael C. K. Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea. Pediatric Research (2019), vol. 85, pp. 790–798.
Rocha, Marina Cavalcante; Oliveira, F. M. Mathematical modeling techniques of the cardiorespiratory system and quantification of the autonomic nervous system: frequency domain analysis. Revista Argentina de Bioingeniería (2018), vol. 22 (3).
Bhatia, Rajeev; Lesser, Daniel; Oliveira, Flavia G. S. A.; Tran, Winston; Keens, Thomas G.; Khoo, Michael C. K.; Davidson-Ward, Sally L. Body fat composition: a predictive factor for sleep related breathing disorder in obese children. Journal of Clinical Sleep Medicine (2015), vol. 11 (9), pp. 1039-1045.
Khoo, M. C.; Oliveira, F. M.; Chen, L. Understanding the metabolic syndrome: a modeling perspective. IEEE Reviews in Biomedical Engineering (2013), vol. 6, March, pp. 143-155.
Lesser, Daniel J.; Bhatia, Rajeev; Tran, Winston H.; Oliveira, Flavia; Ortega, Ricardo; Keens, Thomas G.; Mittelman, Steven D.; Khoo, Michael C. K.; Davidson Ward, Sally L. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males. Pediatric Research (2012), vol.72(1), pp.293-298.
Hoppenbrouwers, Toke; Oliveira, Flavia; Sandarupa, Stanislaus; Khoo, Michael; Neuman, Michael; Ramanathan, Rangasamy. The development of the circadian heart rate rhythm (CHR) in Asian infants. Early Human Development (2012), vol.88(7), pp. 555-561.
Oliveira, F. M. S.; Tran, W. H.; Bhatia, R.; Lesser, D. J.; Chalacheva, P.; Mittelman, S. D.; Keens, T. G.; Ward, S. L. D.; Khoo, M. C. K. Relationships among autonomic dysfunction, obstructive sleep apnea, and insulin resistance in childhood obesity (abstract). Autonomic Neuroscience: Basic and Clinical (2011), vol.163(1-2), p.81.
Conference papers
Souza, Êmilly Késsey F.; Oliveira, Flavia M. S. Quantification of autonomic response to passive change of posture in healthy individuals. XXVI Brazilian Congress on Biomedical Engineering (CBEB 2018), Proceedings (2018). Búzios, RJ, October 21-25, 2018.
Oliveira Júnior, Evandro da Costa; Oliveira, Flavia M. S. Attenuation of vagal modulation with aging: univariate and bivariate analysis of HRV. 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'17), Jeju Island, South Korea, July 11-15, 2017.
Rocha, Marina Cavalcante; Oliveira, F. M. Mathematical modeling techniques of the cardiorespiratory system and quantification of the autonomic nervous system: frequency domain analysis. XXI Congresso Argentino de Bioingeniería (SABI 2017), Proceedings (paper 59), Cordoba, Argentina, October 25-27, 2017.
Oliveira, Flavia M. S.; Bhatia, Rajeev; Lesser, Daniel J.; Tran, Winston H.; Keens, Thomas; Khoo, Michael C. K.; Davidson-Ward, Sally. OSA in obese children: association with autonomic control impairment and glucose metabolic dysfunction. Abstract. 14th International Symposium on Sleep and Breathing, Porto de Galinha, PE, October 26-28, 2015.
Oliveira, F.M; Tran, W.T.; Chalacheva, P.; Khoo, M.C.K. Sleep Apnea in Childhood Obesity: Autonomic and Metabolic Associations. Proceedings, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology (2012).
Oliveira, F. M; Tran, W.; Bhatia, R.; Lesser, D.; Chalacheva, P.; Mittelman, S. D.; Keens, T. G.; Davidson Ward, S. L.; Khoo, M. C. Severity of obstructive sleep apnea predicts autonomic and metabolic dysfunction in obese Hispanic boys. Proceedings, Sleep 2011 - A Joint Meeting of the American Academy of Sleep Medicine and the Sleep Research Society (2011), vol.34, p. A295 (abstract).
Oliveira, F. M.; Tran, W.; Lesser, D.; Bhatia, R.; Ortega, R.; Mittelman, S.; Gora, M.; Keens, T.; Khoo, M. Autonomic and metabolic effects of obstructive sleep apnea in childhood obesity. International Conference from the American Thoracic Society (2010), Am. J. Respir. Crit. Care Med. (2010), vol.181, p. A2541 (abstract).
Bhatia, R.; Lesser, D.; Tran, W.; Oliveira, F.; Keens, T.; Khoo, M.; Ortega, R.; Polonio, V.; Mittelman, S.; Ward, S. L. Dual-energy X-ray absorptiometry (DEXA) analysis of body fat composition and sleep related breathing disorder (SRBD) in obese Latino adolescent males. SLEEP 2010 24th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS) (2010).
Oliveira, Flavia; Tran, Winston; Lesser, Daniel; Bhatia, Rajeev; Ortega, Ricardo; Mittelman, Steven; Keens, Thomas; Davidson Ward, Sally; Khoo, Michael. Autonomic and metabolic effects of OSA in childhood obesity. Proceedings, 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology (2010). p. 6134-6137.
Hoppenbrouwers, T.; Oliveira, F.; Sandarupa, S.; Khoo, M.; Newman, M.; Hodgman, J. Circadian heart rate rhythm in asian infants. Pediatric Academic Societies 2009 Meeting (2009).